Principal Scientist, Target Binding

The role

Generate is seeking an accomplished Principal Scientist to lead Target Binding efforts within our Protein Analytics & Biophysics (PAB) department.

This individual will provide scientific and strategic leadership for protein–protein interaction, target-binding, and cell-binding measurements across multiple biotherapeutic discovery and development programs. The role will combine hands-on technical expertise, novel technology development, cross-functional program leadership, and direct management of junior scientists and research associates.

The successful candidate will be an established industry expert in quantitative biophysical assay development, particularly for challenging systems such as integral membrane proteins, lipid- associated targets, detergent-solubilized proteins, and multispecific molecules.

What you need

Ph.D. in biochemistry, biophysics, analytical chemistry, protein science, chemical biology, or a related discipline, with at least 8+ years of relevant industry experience.

All jobs

Principal Scientist, Target Binding

Generate Biomedicines, Somerville, MA

The role

Generate is seeking an accomplished Principal Scientist to lead Target Binding efforts within our Protein Analytics & Biophysics (PAB) department.

What you need

Ph.D. in biochemistry, biophysics, analytical chemistry, protein science, chemical biology, or a related discipline, with at least 8+ years of relevant industry experience.

About Generate Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.

Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.

Per Year Salary Range

$160,000—$224,000 USD

Principal Scientist, Target Binding

The role

What you need

Principal Scientist, Target Binding

The role

What you need

Nice to have

Here's how you will contribute

About Generate Biomedicines

Similar jobs at other companies

Associate Scientist I, Biochemistry

Senior Research Associate, High-Throughput Protein Binder Screening

Computational Scientist, Assay Development

Senior / Principal Scientist, Molecular Simulations

Scientist II, Antibody Engineering and Characterization

Scientist, cDNA Display

Generate Biomedicines