Scientist I, Computational Protein Design

The role

We are seeking an inventive Computational Protein Design Scientist to join our team working at the interface of computational protein design, machine learning, and experimental biology. In this role, you will use your computational expertise and in-depth biochemical understanding of proteins to drive computational protein design strategy for therapeutic programs while helping develop reusable design capabilities to unlock novel design challenges. The role interfaces between our machine learning and experimental platform teams, working closely to efficiently integrate AI-designed proteins and experimental data.

You will combine hands-on protein design with computational experimentation and close partnership across program, experimental, and computational teams. You will translate therapeutic hypotheses into design and data-generation plans, execute protein design campaigns, interpret results, and help guide decision-making in fast-paced cross-functional teams.

You will also feed back application learning to drive platform capability development by identifying recurring needs, successful approaches, and failure modes. This work will help shape new design methods, workflows, and scientific requirements that make program execution more efficient, reproducible, and scalable.

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Scientist I, Computational Protein Design

Generate Biomedicines, Somerville, MA

The role

About Generate Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.

Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.

Per Year Salary Range

$140,000—$196,000 USD

Scientist I, Computational Protein Design

The role

Scientist I, Computational Protein Design

The role

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Who Will Love This Job

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About Generate Biomedicines

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Generate Biomedicines