Scientist, Mass Spectrometry

Axiom, South San Francisco

The role

Build and run Axiom’s LC-MS/MS experiments to identify drug metabolites, measure changes in cellular metabolism and proteins, and uncover mechanisms of toxicity. Combine analytical expertise with robotics and scientific AI to generate reliable data and teach frontier models to predict human drug outcomes with insane accuracy.

What you will do

Own Axiom’s LC-MS/MS operations across targeted and untargeted workflows, including chromatography, UV detection, mass spectrometry, and supporting equipment.
Develop and run reactive-metabolism assays to identify drug metabolites and trapped reactive intermediates, using isotope-labeled controls to verify signals and support structural interpretation.
Design metabolomics experiments that reveal how drugs alter cellular metabolism, connecting measurements with imaging, transcriptomics, and other indicators of toxicity.
Establish proteomics workflows with Axiom’s biology and computational teams, from sample preparation and digestion through peptide separation and LC-MS/MS acquisition.

What you need

What we look for

Exceptional hands-on LC-MS/MS expertise, with a deep understanding of chromatography, ionization, fragmentation, and targeted and untargeted analysis.
Experience developing and running reactive-metabolism, metabolomics, or proteomics experiments, with the ability to master unfamiliar workflows.
Strong experimental judgment. You design controls, calibration strategies, and validation studies that distinguish real chemical and biological signals from contamination, interference, and instrument artifacts.
The ability to interpret complex spectra and mixtures, assess uncertainty, and recognize when molecular identification requires additional evidence.
Strong troubleshooting and maintenance skills, with the resourcefulness to keep instruments and supporting systems operating reliably.
Excitement about developing experiments that teach AI agents to reason about chemistry, and working with engineers to automate QC, adapt methods, and close the loop between analysis and experimentation.
End-to-end ownership. You identify what matters, move quickly from observation to action, and follow problems through to a verified resolution.
Exacting standards for sample handling, reproducibility, documentation, and data quality, alongside the ability to train technicians and build dependable laboratory practices.
Clear communication, generosity with your expertise, and the curiosity to work across analytical chemistry, biology, computation, and engineering.

Technical skills we value

LC-MS/MS operation and method development, including UHPLC, UV detection, high-resolution MS, and fragmentation methods.
Instrument troubleshooting, preventive maintenance, vacuum systems, nitrogen generators, and sample preparation equipment.
Reactive-metabolite trapping, metabolic incubations, stable-isotope labeling, and metabolite identification.
Targeted and untargeted metabolomics, including extraction, chromatographic separation, and analysis of complex biological matrices.
Proteomics sample preparation, protein digestion, peptide separation, and LC-MS/MS acquisition.
Assay development and qualification, calibration, internal standards, matrix effects, recovery, carryover, and measurement uncertainty.
Spectral interpretation, accurate-mass analysis, isotope patterns, adduct identification, and integration of LC-MS/MS with UV and NMR evidence.
Experimental data analysis using vendor software and tools such as MZmine, OpenMS, MS-DIAL, Skyline, or SIRIUS; Python or R is a plus.
Laboratory automation, instrument interfaces, and AI-assisted workflows for acquisition planning, quality control, and experimental analysis.

Scientist, Mass Spectrometry

The role

What you will do

Scientist, Mass Spectrometry

The role

What you will do

What you need

What we look for

Technical skills we value

About Axiom

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