Founding Engineer
10x Science, San Francisco, California +1
- Pay
- $150K–$240K / year
- Work type
- Not stated
- Level
- Not stated
- Area
- Software engineering, Inference & ML systems, ML / AI engineering
- Posted
- Mar 25, 2026
Check my fit
See how your résumé lines up with this role: where you match, what's missing, and lines worth rewording.
About the role
Why Join
You will be founding engineer #1 or #2 at a company that is already selling to the largest pharmaceutical companies in the world. That is rare at this stage. The code you write will directly determine whether a drug candidate advances or gets stopped: decisions worth hundreds of millions of dollars to our customers and, downstream, the patients waiting for those medicines.
You will pair-program with the founders on hard, novel problems at the intersection of high-performance computing, scientific algorithms, and AI. The founding team has 15+ years of domain expertise in the science our software automates. You will not be guessing at requirements or building to a spec handed down from a PM. No scientific background is required. We will teach you everything you need to know about the domain. What we cannot teach is the drive to move with urgency and the desire to build something that matters.
What 10x Science is Solving
10x Science (YC W26) develops frontier AI models with deep memory to redefine how scientists understand and engineer biology across the life sciences, starting with drug development.
- AI-powered drug discovery is flooding the pipeline with new candidates faster than the industry can evaluate them.
- Before a drug candidate can advance to the clinic, scientists must deeply characterize the protein therapeutic to understand whether it will work.
- Today, that process takes months of manual, error-prone analysis. It is the bottleneck holding back the entire industry.
- Our AI-native platform automates it, giving drug developers the confidence to advance the right candidates and stop the wrong ones early.
The Team
We built the field of next-generation protein characterization out of Carolyn Bertozzi’s Nobel laureate lab at Stanford. No one had turned it into software until now.
- David (Co-Founder, CEO) is a Stanford postdoctoral scholar and Damon Runyon Cancer Research Fellow who has spent 15+ years on the science this platform automates, with foundational publications across the Nature family of journals, the Journal of the American Chemical Society, and other leading scientific publications.
- Andrew (Co-Founder, COO) trained at the Broad Institute of MIT and Harvard, where he built the analytical tools pharma uses to understand how drugs bind their targets, before joining the Bertozzi lab at Stanford.
- Vishnu (Co-Founder, CTO) is a 2x YC founder who was the founding engineer at Nooks and helped scale them through their Series B. You will report directly to Vishnu.
We are already working with multiple top-10 pharma companies and have enterprise contracts in motion. We are well-capitalized and focused on building.
The Role
You will join a three-person founding team and build the core platform from the ground up. You will pair-program directly with the founders on bare-metal, high-throughput, AI-native software that is already being deployed to top-10 pharmaceutical companies.
Similar roles at other companies
Principal Platform Bioengineering & Assay Development
Parallel BioSan Francisco, CA
$178K–$197K / yr
Posted 18 days ago
€60K / yr
Posted Sep 18, 2026
Pay not posted
Posted Jul 14, 2025
Forward-Deployed Scientist
Chai DiscoverySan Francisco office
Pay not posted
Posted Mar 5, 2026
Listed on Y Combinator's job board; checked 31 h ago. First seen by us 31 h ago. Being listed doesn't mean the team is actively interviewing.